Amphetamine exposure during development causes epigenetic trans‐generational changes in drug sensitivity in Caenorhabditis elegans (803.8)
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چکیده
منابع مشابه
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
Chromatinmodifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2,WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabdit...
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Passive and active exposure to tobacco smoking among youth is directly associated with immediate as well as long-term health deterioration. Despite all public health policies and efforts, the percentage of teenage smokers is still relatively high, especially in developing countries. Very few, if any, studies have been done on the transgenerational effect of nicotine exposed during the more sens...
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A recent study by Greer et al. in the nematode C. elegans has shown transgenerational epigenetic inheritance of longevity in the descendants of worms deficient for subunits of a complex responsible for histone H3 lysine 4 trimethylation (H3K4me3). In this commentary, we discuss the implications of this epigenetic memory of longevity and the potential mechanisms underlying this phenomenon. The t...
متن کاملMating can cause transgenerational gene silencing in Caenorhabditis elegans
Gene silencing is a significant obstacle to genome engineering and has been proposed to be a non-self response against foreign DNA. Yet, some foreign genes remain expressed for many generations and some native genes remain silenced for many generations. How organisms determine whether a sequence is expressed or silenced is unclear. Here we show that a stably expressed foreign DNA sequence in C....
متن کاملAMPK blocks starvation-inducible transgenerational defects in Caenorhabditis elegans.
Life history events, such as traumatic stress, illness, or starvation, can influence us through molecular changes that are recorded in a pattern of characteristic chromatin modifications. These modifications are often associated with adaptive adjustments in gene expression that can persist throughout the lifetime of the organism, or even span multiple generations. Although these adaptations may...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.803.8